BSID SKIN CLUB SYMPOSIUM:
Inflammatory Skin Disease
Chairperson: Richard Weller

Genetics of atopic dermatitis: a tail of mice and men
Prof. Padraic Fallon, Trinity College, Dublin

Anti-TNF as a tool to unravel human immunity in patients with rheumatoid arthritis
Prof. Michael Ehrenstein, University College London

Clock genes modulate the human hair cycle: Period1 knock-down in human
hair follicle organ culture prolongs anagen. Y Al-Nuaimi, JE Klatte, BI Tóth, REB Watson, T Biró and R Paus.

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iASPP a novel and essential key regulator of skin homeostasis. A Chikh, R Matin, CA Harwood and D Bergamaschi.

Varicella-zoster replication and its association with keratin 15 expression and
Wnt signalling. M Singh, J Breuer, R Heseltine, R Cerio, J Millar, MP Philpott and EA O'Toole.

Increased type VII collagen in adipose derived stem cell-keratinocyte co-culture compared with dermal fibroblast co-culture is dependent on MMP3. C Pourreyron, C Cole, JA McGrath, IM Leigh and AP South.

The connexin mimetic peptide Gap27 increases cell migration in diabetic conditions in vitro and alters gene expression of dermal fibroblasts. CS Wright and PEM Martin.

Prostaglandin F₂ stimulates human hair follicles via receptors located within
the follicle itself. KG Khidhir, NP Farjo, DF Woodward, SM Picksley and VA Randall.

Keratinocyte-derived factors stimulate fibroblast hyaluronan synthesis: a
possible role in suppression of scar tissue formation. M Edward and JA Quinn.

Demonstration of novel innate immune cells in psoriasis skin. RKH Mak, C Hundhausen, E Botti, K Grys and FO Nestle.

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Priming of adaptive immune responses by different subsets of skin dendritic
cells. ME Polak, L Newell, C Pickard, E Healy and M Ardern-Jones.

Investigating the role of the transcription factor T-bet in the immunopathogenesis of psoriasis. P Di Meglio, Y Umezawa, L Napolitano, E Botti, S Karagiannis and FO Nestle.

The role of invariant natural killer T cells in psoriasis. AM Tobin, A Hogan, L Lynch, S Rogers, P Collins, D O'Shea and B Kirby.

A defect of varicella-zoster specific CD4+ T cell infiltration after cutaneous
antigen challenge in ageing. E Agius, M Vukmanovic-Stejic, KE Lacy, T Sobande, J Breuer, GS Ogg, MH Rustin and AN Akbar.

11:50

Association of decreased CCR5 expression with impaired migration of Langerhans cells (LCs) in early-onset psoriasis. FL Shaw, R Begum, RJ Dearman, I Kimber and CEM Griffiths.

Keynote Guest Lecture
(sponsored by the British Association of Dermatologists)
Desmosomes pull it together: coordinating adhesion and signaling in epidermal differentiation.
Prof. Kathleen Green, Northwestern University, Chicago

UVB induces melanosome transfer via filopodia in human skin cells. SK Singh, C Nizard, R Kurfurst, S Schnebert, E Perrier and DJ Tobin.

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Azathioprine withdrawal results in reduction in UVA photosensitivity but persistence of potentially mutagenic DNA thiopurines. NR Attard, G Hofbauer, G Straub, A Serra, CA Harwood, J McGregor and P Karran.

Melanosomes in pigment cells contain functional MC1R. CL Jackson, SK Singh, SJ Robinson, P Kumar, AM Page, PS Friedmann, DJ Tobin and E Healy.

p63 is implicated in apoptotic dysregulation in melanoma. RN Matin, A Chikh, G Warnes, CM Proby, IM Leigh, CA Harwood and D Bergamaschi.

British Photodermatology Group Guest Lecture
The measurement of UVR-induced DNA damage in the skin and urine
Prof. Dan Segerbäck, Karolinska Institute, Stockholm

Lhx2 transcription factor controls the activity of epithelial stem cells in the skin during tumourigenesis and wound healing. AN Mardaryev, AA Sharov, TY Sharova, MY Fessing and VA Botchkarev.

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The role of the receptor tyrosine kinase Axl in intercellular adhesion and signalling in cancer. MA Cichon, IC Mackenzie and EA O'Toole.

Dysregulated tropomyosin receptor kinase (Trk) signalling in CYLD^trunc/trunc tumours. N Rajan, CJ Lord, O Clewes, J Burn, M Sieber-Blum and A Ashworth.

Sonic Hedgehog is not enough to create basal cell carcinoma in vitro. C Searby, CM Heard and RM Porter.

Identification of polo-like kinase 1 as a potential therapeutic target in squamous cell carcinoma. SA Watt, C Pourreyron, J Foerster, C Hogan, K Purdie, L Bruckner-Tuderman, C Proby, JA McGrath, IM Leigh and AP South.

PTPRD microdeletions are associated with metastatic cutaneous squamous
cell carcinoma. SR Lambert, K Purdie, A Gulati, IM Leigh, DP Kelsell, CA Harwood and C Proby.

The role of Vgamma9 Vdelta2 gamma delta T cells in malignant melanoma. U Laggner, M Harries, A Hayday, F Nestle and K Lacy.

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MicroRNA-31 regulates a complex program of gene expression during hair cycle and associated tissue remodeling. MI Ahmed, AN Mardaryev, N Vlahov, AA Sharov and NV Botchkareva.

Replication of eczema susceptibility loci identified from a genome-wide association study. SJ Brown, GM O'Regan, LE Campbell, HJ Cordell, AD Irvine and WHI McLean.

Protease-antiprotease imbalance: a potential confounder in the pathogenesis of eczema. SP Tan, R Weller and SB Brown.

Translational development of ex vivo gene therapy for Netherton syndrome. E Semenova, W Qasim, F Larcher, G Talbot, AJ Thrasher, JI Harper and WL Di.

Distinguished Local Guest Lecturer
Regulation of inflammatory responses by clearance of dying cells
Professor Sir John Savill, University of Edinburgh