BSID SKIN CLUB SYMPOSIUM:
Drug delivery and the skin
Chairperson: Richard Weller

Graham Ogg, Chairman BSID

Assessment of topical bioavailability
Prof. Richard Guy, University of Bath

British Association of Dermatologists sponsored talk:
Overcoming delivery issues in developing siRNA therapeutics
Dr Roger Kaspar, CEO, TransDerm Inc., Santa Cruz, CA, USA

Activation of PPAR delta in vivo is sufficient to cause psoriasis-like disease and replicates transcriptional dysregulation. M Romanowska, CN Palmer and JP Foerster.

02

MicroRNAs in hair-cycle-dependent gene regulation, hair growth control and associated tissue remodeling. A Mardaryev, MI Ahmed and N Botchkareva.

AKT-dependent protein phosphatase 2A activity is necessary for epidermal barrier function and the correct formation of the cornified layer. RFL O'Shaughnessy, JC Welti and CR Byrne.

Lysophosphatidic acid-evoked calcium fluxes promote NFAT-mediated keratinocyte migration. R Jans, AM Brown, S Sikkink, K Ross and NJ Reynolds.

Varicella zoster virus infection in skin shows prominent involvement of adnexal stem cell compartments. M Singh, J Breuer, R Heseltine, J Millar, MP Philpott and EA O'Toole.

Investigation of the spatio-temporal expression pattern of the antimicrobial peptide, LL-37, in the development and resolution of psoriasis. GK Perera, D Kassen and FO Nestle.   

A role for STAT4 during mitosis of keratinocytes. C Ferreli, C Pickard, S August, Y Buggy, MR Ardern-Jones, PS Friedmann and E Healy.

The identification of primary human cutaneous squamous cell carcinoma stem cells. GK Patel, CL Yee and JC Vogel.

09

Targeting XIAP to increase endoplasmic reticulum (ER) stress-induced apoptosis of malignant melanoma. EL Hiscutt, DS Hill, S Martin, R Flockhart, JL Armstrong, S Fulda and PE Lovat.

Mechanisms of increased invasion of cutaneous squamous cell carcinoma cells with loss of type VII collagen. VL Martins, JJ Vyas, M Chen, KJ Purdie, AP South, A Storey, JA McGrath and EA O'Toole.

DUSP23, SLCO1B3, SNURF, SNRPN and TJAP1 are genes with differential expression in squamous cell carcinoma keratinocytes derived from patients with recessive dystrophic epidermolysis bullosa. CL Cole, J Foerster, C Pourreyron, K Purdie, C Hogan, C Proby, L Bruckner-Tuderman, JA McGrath, IM Leigh and AP South.

Ras^Ha activation in Fos/PTEN^null skin carcinogenesis interdicts a p53/p21-induced keratoacanthoma aetiology and while p53 loss elicits conversion retention of p21 limits malignant progression. FH MacDonald, D Yao, JA Quinn and DA Greenhaigh.

12:00

Changes in the density of functioning skin lymphatics around human melanoma. V Akhras, AWB Stanton, RH Mellor, JR Levick and PS Mortimer.

Keynote Guest Speaker
Parallels between wound repair and cancer
Prof. Sabine Werner, Swiss Federal Institute of Technology, Zürich, Switzerland

Ciclosporin treatment induces oxidative DNA damage. NR Attard, CA Harwood, J McGregor and P Karran.

15

Real-time imaging of UVB-induced keratinocyte apoptosis to determine duration of apoptosis and effect on tissue turnover. SC Weatherhead, D Jamieson and NJ Reynolds.

Overexpression of GLI2 in human keratinocytes results in polyploidy and resistance to UVB induced apoptosis. E Pantazi, G Trigianti, G Warnes, E Gemenetzidis, M-T Teh and MP Philpott.

UV labile NO stores in the skin may have beneficial cardiovascular effects. S Abeyakirthi, M Mowbray and R Weller.

British Photodermatology Group Guest Lecture
TBA
Prof. Peter Karran, London Research Institute, Cancer Research UK

Innate immune function for HLA-Cw6 in psoriasis: reduced expression of HLA-Cw6 facilitates TNF-alpha release due to impaired interaction with inhibitory receptor KIR2DL1. C Hundhausen, R Mak, E Botti, U Laggner, M Marget and FO Nestle.

19

Sensitisation with DNCB results in skewed T cell polarisation in atopic dermatitis. EL Newell, ME Polak, C Pickard, E Healy, PS Friedmann and MR Ardern-Jones.

Trichohyalin - a potential major autoantigen in human alopecia areata. MC Leung, DA Fenton, CW Sutton and DJ Tobin.

The skin homing Vgamma9 Vdelta2 T cell - a potential role in psoriasis? U Laggner, P di Meglio, C Hundhausen, G Perera, E Botti, R Mak, AC Hayday and FO Nestle.

Skin derived dendritic cell control of T cell activation. ME Polak, L Newell, E Healy and MR Ardern-Jones.

Impaired tumour necrosis factor-alpha-induced Langerhans' cell (LC) migration in early-onset psoriasis: no systemic effect on dendritic cells (DC). FL Shaw, R Begum, M Cumberbatch, RJ Dearman, I Kimber and CEM Griffiths.

TNF-alpha synthesis by macrophages is impaired during secondary cutaneous immune responses in old subjects. E Agius, K Lacy, M Vukmanovic-Stejic, AP Papageorgiou, S Hall, JR Reed, J Curnow, LS Taams, AL Jagger, J Fuentes-Duculan, C Buckley, M Salmon, J Krueger, J Greenwood, N Klein, M Rustin and AN Akbar.

25

CDKAL1, a possible genetic link between Crohn's disease, psoriasis and type 2 diabetes. M Quaranta, F Capon, MA Allen, AD Burden, R Warren, R Smith, H Young, CEM Griffiths, J Worthington, RC Trembath and JNWN Barker.

Skin fragility in AEC syndrome is associated with reduced expression of the basement membrane-associated protein FRAS1. SE Clements and JA McGrath.

Reduced expression of basal keratinocyte stem cell markers and altered integrin profiles in Kindler syndrome skin. JE Lai-Cheong, A Tanaka, M Parsons and JA McGrath.

A role for p63 in establishing tissue-specific chromatin organisation and high-order chromatin remodelling in epidermal keratinocytes during skin development. MY Fessing, AN Mardaryev, M Gdula, AA Sharov, TY Sharova, AA Panteleyev, C Missero and VA Botchkarev.

Local Guest Speaker
Promoting immune regulation as a therapeutic strategy for allergic and autoimmune diseases
Prof. David Wraith, University of Bristol