BSID SKIN CLUB SYMPOSIUM:
Defending the skin
Chairperson: Richard Weller

Graham Ogg, Chairman BSID

When the skin window is open
Prof. Thomas Bieber, University of Bonn, Germany

Role of keratinocytes in defending the skin
Prof. Jens-M Schröder, University of Kiel, Germany

BAD Roadshow
Dr Clive Archer (Bristol) & Dr David Eedy (Portadown)

Akt-dependent, PP2A-mediated formation of tight junctions is an initial component of the epidermal permeability barrier. RFL O'Shaughnessy, JC Welti and CR Byrne.

02

Analysing isoform and tissue-specific functions of desmoplakin. RM Cabral, EE Norgett, AP South and DP Kelsell.

Premature senescence of balding dermal papilla cells in vitro is associated with p16^INK4a expression and identifies environmental stress as a potential mechanism of androgenetic alopecia. AW Bahta, N Farjo, B Farjo and MP Philpott.

Connexin mimetic peptides enhance wound closure rates in human fibroblasts and keratinocytes in vitro. CS Wright, MB Hodgins and PE Martin.

StAR role for glucocorticoid synthesis in keratinocytes. RF Hannen, AE Michael, J Burrin and M Philpott.

Non-neuronal functions of transient receptor potential A1 (TRPA1) in human skin. R Atoyan, D Shander and N Botchkareva.

RANK stimulation of keratinocytes results in activation of AKT but not NFkappaB and regulates epidermal thickness. J-BO Barbaroux, CG Mueller and RW Groves.

Selective inhibition and killing of melanoma cells by a p16-based peptide. JK Soo, DC Kallenberg and DC Bennett.

09

Loss of type VII collagen in SCC results in increased invasion with disorganised epithelial differentiation and EMT. VL Martins, JJ Vyas, KJ Purdie, M Chen, JA McGrath, A Storey, AP South and EA O'Toole.

Gene expression profiling of cultured squamous cell carcinoma keratinocytes identifies a pattern of gene expression which predicts invasive capacity. AP South, C Pourreyron, J Foerster, X Mao, K Purdie, C Hogan, C Mein, L Bruckner-Tuderman, C Proby, B Young, DP Kelsell, JA McGrath and IM Leigh.

A role for the receptor tyrosine kinase, Axl, in cutaneous squamous cell carcinoma survival. ES Papadakis, JJ Vyas, A Storey and EA O'Toole.

NFAT signaling in malignant melanoma. RJ Flockhart, NJ Reynolds and PE Lovat.

12:00

GLI1 repression of EGFR-ERK signalling may account for the poor metastatic potential of basal cell carcinoma. GW Neill, W Harrison, M Ikram, T Williams, L Bianchi, S Nadendla, EA O'Toole, F Aberger and MP Philpott.

Keynote Guest Speaker
Varicella Zoster virus and the skin: a marriage of convenience
Prof. Judy Breuer, Barts and The London School of Medicine and Dentistry

Biochemical and functional association of kindlin-1 with kindlin-2 and migfilin in human keratinocytes. JE Lai-Cheong, IR Hart and JA McGrath.

15

A lack of epidermal urocanic acid (UCA) in histidinaemic skin influences UVB-induced CD1a + Langerhans' cell (LC) trafficking. J Tye, JH Walter, CEM Griffiths and NK Gibbs.

Resistance of keratinocyte stem cells to apoptosis. H Wray, A Storey and H Navsaria.

Lycopene protects against biomarkers of photodamage in human skin. M Rizwan, I Rodriguez-Blanco, A Harbottle, M Birch-Machin, REB Watson and LE Rhodes.

British Photodermatology Group Guest Lecture
Mad dogs and Englishmen: exposure and behaviour in the sun
Prof. Brian Diffey, University of Newcastle

An investigation of cutaneous cytokine expression in aged skin. S Ogden, M Cumberbatch, RJ Dearman, I Kimber and CEM Griffiths.

19

Endothelial activation is impaired in old skin secondary cutaneous memory immune responses in vivo. E Agius, K Lacy , M Vukmanovic-Stejic, S Hall, N Klein, M Rustin and AN Akbar.

Phenotypic analysis of human CD4 + T cells specific for immediate early 63 protein of varicella zoster virus. L Jones, AP Black, GN Malavige and GS Ogg.

The role of interleukin (IL)-2 in the early stages of 2,4-Dinitro- chlorobenzene (DNCB) induced Langerhans' cell migration. C Portsmouth, M Cumberbatch, RJ Dearman, CEM Griffiths and I Kimber.

Migration of immunocytes across the basement membrane in skin: the role of basement membrane pores. ME Oakford, SV Dixon, SJ Harvey, C Pickard, P Lackie, PS Friedmann and E Healy.

An inducible transgenic mouse model of psoriasis. MH Allen, T Silberzahn, M Simon, G Serre, AC Hayday and JNWN Barker.

25

Tumor-suppressor function of the BMP signaling in skin is modulated by BMP antagonist Noggin. A Mardaryev, A Sharov, T Sharova, R Atoyan, M Grachtchouk, HR Byers, P Overbeek, A Dlugosz and VA Botchkarev.

Epigenetic silencing of the Fas gene promoter in cutaneous T-cell lymphoma. CL Jones, EM Wain, S Ferreria, GE Orchard, SJ Whittaker and TJ Mitchell.

Reproducible and stable transgene expression towards ex vivo lentiviral gene therapy for Netherton Syndrome. GE Talbot, W Qasim, AJ Thrasher, JI Harper and WL Di.

Elucidating the Role of ABCA12 in Harlequin Ichthyosis. D Tattersall, AC Thomas, EA O'Toole and DP Kelsell.

Local Guest Speaker
Challenges of HIV vaccine development
Prof. Andrew McMichael FRS, University of Oxford