Risk Factors for Skin Cancer in an Ageing Population
Dr John Lear, Dermatopharmacology, University of Manchester, UK

The basis of defective cutaneous immunity during ageing
Prof. Arne Akbar, Dept of Immunology and Molecular Pathology, University College London, UK

A synonymous SNP in human cystatin A, a candidate gene in the PSORS5 locus, confers susceptibility to psoriasis. Y Vasilopoulos, MJ Cork, GS Sagoo, SJ Ward, GW Duff and R Tazi-Ahnini.

02

Development of preimplantation genetic diagnosis for Herlitz junctional epidermolysis bullosa. H Fassihi, PJ Renwick, PR Braude and JA McGrath.

Functional effects of pachyonychia congenita type I mutations on keratinocyte migration. CJ Fitchett, R Van Koningsveld, EL Rugg and EA O'Toole.

Genetic and functional mechanisms of ABCA12 associated Harlequin ichthyosis. AC Thomas, EE Norgett, T Cullup, EA O'Toole and DP Kelsell.

Phosphorylation of heat shock protein (HSP27) during differentiation of human epidermis and cultured keratinocytes. MS Jehani and PE Bowden.

Signalling mechanisms of squamous cell carcinoma in an in vitro model of squamous cell carcinogenesis. JJ Vyas, CM Proby, A Storey and EA O'Toole. 

Peptide modification of alpha-MSH to enhance penetration into skin. P Kumar, MA Fara, M Bradley, PS Friedmann and E Healy.

Thioguanine nucleotides in patients with moderate-to-severe atopic eczema treated with azathioprine. SJ Meggitt, NJ Reynolds, H Anderson, G Taylor, AG Hall and LA Hogarth.

09

Superantigen-allergen synergy: a novel mechanism of cutaneous atopic disease. MR Ardern-Jones, AP Black, EA Bateman and GS Ogg.

An investigation of acute social stress on epidermal Langerhans' cell frequency. L Schneider, E Kleyn, M Cumberbatch, RJ Dearman, C Smith, HL Richards, I Kimber and CEM Griffiths.

Distinct keratinocyte transcriptional responses to cytokines of the innate and adaptive immune systems. JB Mee, N Morar and RW Groves.

Lithium and glycogen synthase kinase 3-beta regulate proliferation of human keratinocytes. PJ Hampton and NJ Reynolds.

12:00

Nitric oxide is non-inflammatory in human skin. X Tan, M Mowbray, R Morris and RWeller.

Keynote Guest Speaker sponsored by Schering Plough
Immunobiology of psoriasis.
Prof. Frank Nestle, St John's Institute of Dermatology, King's College London, UK

No effect of melanocortin 1 receptor genotype on cyclobutane pyrimidine dimer formation and p53 upregulation in murine skin following exposure to a single dose of ultraviolet radiation. S Robinson, S Dixon and E Healy.

15

Melanocortin 1 receptor (MC1R) genotype influences erythemal sensitivity and treatment response in PUVA patients. G Smith, MJV Wilkie, YY Deeni, J Ferguson, CRWolf and SH Ibbotson.

Age-related deterioration in the mechanical function of human dermal fibrillin microfibrils. MJ Sherratt, JY Bastrilles, JJ Bowden, REB Watson and CEM Griffiths.

A photo-ageing associated mitochondrial DNA mutation with potential functional consequences. MJ Birket, T Vonzglinick and MA Birch-Machin.

British Photodermatology Group Guest Lecture
XPD: One gene, two functions, three disorders
Prof Alan Lehmann, Genome Damage and Stability Centre, University of Sussex, UK

Skin immune responses may be characterised by distinct cutaneous cytokine secretion profiles. M Cumberbatch, C Portsmouth, RJ Dearman, CEM Griffiths and I Kimber.

19

Tumor necrosis factor-alpha and IL-4-independent development of Langerhans cell-like dendritic cells from M-CSF-conditioned precursors. J-B O Barbaroux, W-H Kwan, CG Mueller and RW Groves. 

Dissociation of cutaneous and systemic immunity with ageing. KE Lacy, M Vukmanovic-Stejic, JR Reed, A Akbar and MHA Rustin.

21

Overexpression of the GLI oncoproteins induces characteristics of a senescenct phenotype in keratinocytes. T Williams, G Trigiante, MP Philpott and GW Neill.

Fenretide-induced apoptosis via endoplasmic reticulum stress - new drug targets for melanoma therapy? P Lovat, A Harbottle, M Corazzari, J Armstrong, M Piacentini, C Redfern and M Birch-Machin.

Axl expression in keratinocytes promotes invasion with degradation of the basement membrane. JJ Vyas, W Ahmed, VLC Martins, A Storey and EA O'Toole.