BSID SKIN CLUB SYMPOSIUM:
Pathogenesis of complex disease
Chairman: Richard Weller

Graham Ogg, Chairman BSID
Hywel Williams, local organiser and Chairman BEES

Developmental influences on health and disease: mechanistic and evolutionary insights
Prof. Keith Godfrey, University of Southampton

Akt signalling, foetal skin barrier formation and environmental defence in the adult
Dr Carolyn Byrne, Queen Mary, University of London

The role of the environment in childhood eczema
Prof. Hywel Williams, University of Nottingham

UK Professors of Dermatology meeting
Prof. Jonathan Rees, University of Edinburgh

Intradermal injection of allogeneic normal human fibroblasts promotes type VII collagen deposition at the dermal-epidermal junction in individuals with recessive dystrophic epidermolysis bullosa. T Wong, L Gammon, L Liu, L Ozoemena, PJC Dopping-Hepenstal, C Jones, IM Leigh, H Navsaria and JA McGrath.

02

Human dermal fibroblasts ameliorate in vitro graft versus host reactions and are functionally indistinguishable from bone marrow mesenchymal stromal cells. MA Haniffa, XN Wang, U Holtick, MC Rae, S Alshemali, NJ Reynolds, AM Dickinson, JD Isaacs, CMU Hilkens and MP Collin.

Location, mobility and secretion of cyclophilin B in keratinocytes is regulated through its Ciclosporin A binding site. AA Lonsdale-Eccles, P Fearon, K Ross, F Allain and NJ Reynolds.

Keratinocyte apoptosis induced by allergen-specific T cells. MR Ardern-Jones, AP Black and GS Ogg.

Langerhans' cell migration provoked by interleukin-1beta proceeds normally in uninvolved skin of patients with late-onset psoriasis. M Cumberbatch, E Kleyn, N Khan, RJ Dearman, I Kimber and CEM Griffiths.

Early changes in draining lymph node cell activation following topical exposure to chemical contact and respiratory allergens. C Portsmouth, M Cumberbatch, R Dearman, CEM Griffiths and I Kimber.

Acidified nitrite speeds wound healing in diabetic and non-diabetic mice. M Finnen and R Weller.

The R381Q variant of the interleukin 23 receptor gene (IL23R) confers protection against psoriasis vulgaris. F Capon, P di Meglio, M Allen, L Baumber, D Burden, JNWN Barker, RC Trembath and FO Nestlé.

09

The Effect of Pachyonychia Congenita type I mutations in keratinocyte adhesion and desmosome formation and associated signal transduction. R Van Koningsveld, CJ Fitchett, EL Rugg, DP Kelsell and EA O'Toole.

Analysis of WT and mutant Cx31 reveal non-gap junction functions and altered cell signaling. D Tattersall, CA Scott, T Aasen, HC Unsworth and DP Kelsell.

Single nucleotide polymorphisms in adenosine receptors and response to methotrexate therapy in psoriasis. RB Warren, RL Smith, E Campalani, CH Smith, JNWN Barker, J Worthington and CEM Griffiths.

A proteomic approach to identify targets of LEKTI - a protein implicated in the barrier function of the skin. K Bennett, K Mills, RE Callard, JI Harper and WL Di.

12:00

Allelic Imbalances and Microdeletions Affecting the PTPRD Gene in Cutaneous Squamous Cell Carcinomas Detected Using SNP Microarray Analysis. K Purdie, S Lambert, M Teh, T Chaplin, G Molloy, M Raghavan, DP Kelsell, IM Leigh, CA Harwood, B Young and C Proby.

Keynote Guest Speaker
The pathogenesis of ectodermal dysplasia syndromes
Prof. Irma Thesleff, University of Helsinki, Finland

Ultraviolet B radiation upregulates arginase in human epidermis via a nitric oxide dependent pathway. M Mowbray, N Bredenkamp, L Van Overloop, L Declercq and R Weller.

15

UVA induces rapid photolysis of NO stores in human skin. M Mowbray and R Weller.

Epidermal akt signalling regulates SREBP transcription, epidermal lipogenesis and skin barrier activity. JC Welti, RFL O'Shaughnessy and C Byrne.

Ultraviolet irradiation directly influences the structure of fibrillin microfibrils. SM Reilly, NK Gibbs, CEM Griffiths, REB Watson and MJ Sherratt.

British Photodermatology Group Guest Lecture
Sunlight and skin cancer: lessons from the immune system
Prof. Steve Ullrich, University of Texas, USA

How "atopic" is flexural eczema? Findings from the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Two. C Flohr, SK Weiland, HC Williams and the ISAAC Phase Two Study Group.

19

A comprehensive survey of 28 candidate genes for atopic eczema using a hapTAG approach in a unique Bangladeshi population of east London. C Sinclair, EA O'Toole, D Paige, CA Mein and DP Kelsell.

Regular anti-helminthic therapy increases allergen skin sensitisation: a randomised, double blind, placebo-controlled trial in Vietnam. C Flohr, LN Tuyen, S Lewis, R Quinnell, TT Minh, J Campbell, D Pritchard, TT Hien, J Farrar, J Britton and HC Williams.

21

The role of type VII collagen in squamous cell carcinoma (SCC) invasion in recessive dystrophic epidermolysis bullosa. VL Martins, JJ Vyas, KJ Purdie, M Chen, JA McGrath, A Storey, AP South and EA O'Toole.

Combining ER-stress inducing agents with protein disulphide inhibitors as a novel therapeutic strategy for metastatic melanoma. PE Lovat, CPF Redfern and MA Birch-Machin.

RANK is a regulator of keratinocyte growth and apoptosis: potential role in cutaneous malignancy. J-B O Barbaroux, CG Mueller and RW Groves.

Defining the role of B-RAF-induced ERK kinase in the resistance of metastatic melanoma to apoptosis. DS Hill, JL Armstrong, MA Birch-Machin and PE Lovat.

Local Guest Speaker
Drugs from bugs: a tale of worms, maggots and bacteria
Professor David Pritchard, University of Nottingham (food for thought?)